gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0118 ::
FAMILY Tyr protein kinases
SUBFAMILY Tyr protein kinases
TYPE Burtons tyrosine kinase

Cross References:
UniProt Q06187 | Q32ML5 EMBL X58957 | U10087 | U10084 | U10085 | U10086 | L31572 | L31557 | L31558 | L31559 | L31561 | L31563 | L31564 | L31565 | L31566 | L31567 | L31568 | L31569 | L31570 | L31571 | U13433 | U13410 | U13412 | U13413 | U13414 | U13415 | U13416 | U13417 | U13422 | U13423 | U13424 | U13425 | U13427 | U13428 | U13429 | U13430 | U13431 | U13
InterPro IPR001562 | IPR001849 | IPR011993 | IPR000719 | IPR000980 | IPR001452 | IPR001245 | IPR008266 PDB 1AWW | 1AWX | 1B55 | 1BTK | 1BWN | 1K2P | 1QLY | 2GE9
PRODOM PD000001 | PD000093 | PD000066 GENEID 695 MIM 300300 | 307200
PRINTS PR00401 | PR00452 | PR00402 | PR00109 PFAM PF00779 | PF00169 | PF07714 | PF00017 | PF00018

Details:
NAME Burton's tyrosine kinase-Homo sapiens-2
DESCRIPTION Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase)(Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase)(BPK).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE BTK | AGMX1 | ATK | BPK
SEQUENCE 
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEK
ITCVETVVPEKNPPPERQIPRRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEEL
RKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSS
HRKTKKPLPPTPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMNANDLQLRKGDE
YFILEESNLPWWRAR
 FRAGMENT NO
FUNCTION Plays a crucial role in B-cell ontogeny
Interacting with G-proteins:
Family:Gq/11 REFERENCES:15251227 | 9305846 | 16182515
1GPR0002Galpha-q-Homo sapiens-2
2GPR0237Galpha-q-Homo sapiens-1
Family:Gbeta REFERENCES:15251227 | 11698416
3GPR0147Gbeta-1-Homo sapiens
4GPR0155Gbeta-2-Homo sapiens
5GPR0160Gbeta-3-Homo sapiens-1
6GPR0164Gbeta-4-Homo sapiens
7GPR0167Gbeta-5-Homo sapiens-2
8GPR0363Gbeta-3-Homo sapiens-2
9GPR0366Gbeta-5-Homo sapiens-1
10GPR0402unclassified_Gbeta-Homo sapiens
Family:Ggamma REFERENCES:15251227 | 11698416
11GPR0176Ggamma-t1-Homo sapiens
12GPR0179Ggamma-2-Homo sapiens
13GPR0183Ggamma-3-Homo sapiens
14GPR0185Ggamma-4-Homo sapiens
15GPR0188Ggamma-5-Homo sapiens-2
16GPR0192Ggamma-7-Homo sapiens
17GPR0195Ggamma-8-Homo sapiens-2
18GPR0198Ggamma-10-Homo sapiens-2
19GPR0199Ggamma-11-Homo sapiens
20GPR0203Ggamma-12-Homo sapiens
21GPR0205Ggamma-13-Homo sapiens
22GPR0210Ggamma-8-Homo sapiens-1
23GPR0253Ggamma-5-Homo sapiens-1
24GPR0364Ggamma-10-Homo sapiens-1

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