gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0443 ::
FAMILY Guanine nucleotide exchange factors
SUBFAMILY RhoGEFs
TYPE p115 RhoGEF

Cross References:
UniProt Q92888 | O00513 | Q8N4J4 | Q96BF4 | Q96F17 | Q9BSB1 EMBL U64105 | BC005155 | BC011726 | BC015652 | BC034013 | Y09160 | BT007421
InterPro IPR000219 | IPR001331 | IPR001849 | IPR011993 | IPR015212 | IPR015721 PDB 1IAP | 1SHZ
GENEID 9138 MIM 601855
PFAM PF09128 | PF00621

Details:
NAME p115 RhoGEF-Homo sapiens
DESCRIPTION Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF)(115 kDa guanine nucleotide exchange factor) (Sub1.5).
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE ARHGEF1
SEQUENCE 
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
ALLQHVALQFEPGPLLCCLHADMLGSLGPKEAKKAFLDFYHSFLEKTAVLRVPVPPNVAF
ELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQLEDFRSKRLMGMTPWEQELAQLEAWVG
RDRASYEARERHVAERLLMHLEEMQHTISTDEEKSAAVVNAIGLYMRHLGVRTKSGDKKS
GRNFFRKKVMGNRRS
 FRAGMENT NO
FUNCTION Seems to play a role in the regulation of RhoA GTPase bys guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)s subunits
Interacting with G-proteins:
Family:G12/13 REFERENCES:15251227 | 14607242
1GPR0034Galpha-12-Homo sapiens
2GPR0037Galpha-13-Homo sapiens
Family:Gq/11 REFERENCES:1525227 | 16182515
3GPR0002Galpha-q-Homo sapiens-2
4GPR0237Galpha-q-Homo sapiens-1

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