gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::Effector View
Entry 1 of 1 :: EFF0573 ::
FAMILY PI3/PI4 kinases
SUBFAMILY Class Ia PI3Ks
TYPE PI3K alpha

Cross References:
UniProt P42337 EMBL U03279
InterPro IPR000008 | IPR000403 | IPR002420 | IPR003113 | IPR000341 | IPR001263 | IPR015433
GENEID 18706
PFAM PF00454 | PF00792 | PF02192 | PF00794 | PF00613

Details:
NAME PI3K alpha-Mus musculus
DESCRIPTION Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alphaisoform (EC 2.7.1.153) (PI3-kinase p110 subunit alpha) (PtdIns-3-kinase p110) (PI3K).
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Pik3ca
SEQUENCE 
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFREARKYPLHQ
LLQDETSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVC
 FRAGMENT NO
FUNCTION Phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with as preference for PtdIns(4,5)P2
Interacting with G-proteins:
Family:Gq/11 REFERENCES:16182515
1GPR0240Galpha-q-Mus musculus
Family:Gbeta REFERENCES:16182515
2GPR0148Gbeta-1-Mus musculus
3GPR0156Gbeta-2-Mus musculus
4GPR0161Gbeta-3-Mus musculus
5GPR0165Gbeta-4-Mus musculus
6GPR0168Gbeta-5-Mus musculus-2
7GPR0291unclassified_Gbeta-Mus musculus-1
8GPR0318unclassified_Gbeta-Mus musculus-2
9GPR0376Gbeta-5-Mus musculus-3
10GPR0377Gbeta-5-Mus musculus-1
Family:Ggamma REFERENCES:16182515
11GPR0178Ggamma-t1-Mus musculus
12GPR0181Ggamma-2-Mus musculus
13GPR0184Ggamma-3-Mus musculus
14GPR0186Ggamma-4-Mus musculus
15GPR0189Ggamma-5-Mus musculus
16GPR0193Ggamma-7-Mus musculus
17GPR0196Ggamma-8-Mus musculus-2
18GPR0200Ggamma-11-Mus musculus
19GPR0204Ggamma-12-Mus musculus
20GPR0206Ggamma-13-Mus musculus
21GPR0211Ggamma-8-Mus musculus-1
22GPR0349Ggamma-1-Mus musculus
23GPR0379Ggamma-10-Mus musculus

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