gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1218 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY MELATONIN RECEPTOR
SUBFAMILY MT1

Cross References:
UniProt P48040 | O46608 EMBL U14109 | AF045219
InterPro IPR000276 | IPR002278 | IPR000025 GPCRDB MTR1A_SHEEP
GENEID 443022
PRINTS PR00237 | PR01149 | PR00857 PFAM PF00001

Details:
NAME MELATONIN RECEPTOR_MT1_Ovis aries
DESCRIPTION Melatonin receptor type 1A (Mel-1A-R) (Mel1a melatonin receptor).
SPECIES Ovis aries COMMON NAME Sheep NCBI Taxonomy 9940
GENE MTNR1A
SEQUENCE 
MAGRLWGSPGGTPKGNGSSALLNVSQAAPGAGDGVRPRPSWLAATLASILIFTIVVDIVG
NLLVVLSVYRNKKLRNAGNVFVVSLAVADLLVAVYPYPLALASIVNNGWSLSSLHCQLSG
FLMGLSVIGSVFSITGIAINRYCCICHSLRYGKLYSGTNSLCYVFLIWTLTLVAIVPNLC
VGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMLVVVFCYLRIWALVLQVRWKVKPD
NKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLVVASDPASMAPRIPEWLFVASYYMA
YFNSCLNAIIYGLLNQNFRQEYRKIIVSLCTTKMFFVDSSNHVADRIKRKPSPLIANHNL
IKVDSV
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583
HETERODIMER INFORMATION Forms heterodimers with Melatonin MT2 Receptors. METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11940583

Coupling with G-proteins:
No information

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athina University of Athens
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 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory