gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0171 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADENOSINE RECEPTOR
SUBFAMILY A1

Cross References:
UniProt Q8R0M5 EMBL BC026602
InterPro IPR001068 | IPR001634 | IPR000276 GPCRDB Q8R0M5_MOUSE
PRINTS PR00552 | PR00424 | PR00237 PFAM PF00001

Details:
NAME ADENOSINE RECEPTOR_A1_Mus musculus-1
DESCRIPTION Adora1 protein .
SPECIES Mus musculus COMMON NAME Mouse NCBI Taxonomy 10090
GENE Adora1
SEQUENCE
VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTY
FHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSL
VVGLTPMFGWNNLSEVEQAWIANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLM
VLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCI
TLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIE
EDIPEEKADD
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12123822
HETERODIMER INFORMATION Forms heterodimers with Dopamine D1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919
HETERODIMER INFORMATION Forms heterodimers with Metabotropic Glutamate Receptor 1. Dimerization results in alteration of signalling METHOD Immunoprecipitation REFERENCES 11278325
HETERODIMER INFORMATION Forms heterodimers with P2Y1 Receptors. Heterodimerization results in altered ligand binding METHOD Immunoprecipitation, Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 11390975 | 12417330 | 12123822

Coupling with G-proteins:
Family:Gi/o REFERENCES:1662665
1GPR0021Galpha-o1-Mus musculus
2GPR0227Galpha-i2-Mus musculus-2
3GPR0289Galpha-i1-Mus musculus
4GPR0331Galpha-i2-Mus musculus-1
5GPR0385Galpha-i3-Mus musculus


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athina University of Athens
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Biophysics
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Laboratory