gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR1909 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY OPIOID AND OPIOID-LIKE RECEPTOR
SUBFAMILY MU OPIOID PEPTIDE (MOR)

Cross References:
UniProt Q95247 EMBL L38645 | AF521309
InterPro IPR000276 | IPR000105 | IPR001418 GPCRDB OPRM_PIG
GENEID 396802
PRINTS PR00237 | PR00537 | PR00384 PFAM PF00001

Details:
NAME OPIOID AND OPIOID-LIKE RECEPTOR_MU OPIOID PEPTIDE (MOR)_Sus scrofa
DESCRIPTION Mu-type opioid receptor (MOR-1).
SPECIES Sus scrofa COMMON NAME Pig NCBI Taxonomy 9823
GENE OPRM1
SEQUENCE
MDSSADPRNASNCTDPFSPSSMCSPVPSPSSWVNFSHLEGNLSDPCIRNRTELGGSDSLC
PPTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALA
TSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALD
FRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRNGSIDCALTFSHPTWYWENLLKICVF
IFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIH
IYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSST
IEQQNSARIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12217652
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10842167
HETERODIMER INFORMATION Forms heterodimers with delta Opioid Peptide Receptor. Dimerization results in Changing the binding properties of opiate ligands and altered G-protein coupling METHOD Immunoprecipitation REFERENCES 10842167 | 11069979
HETERODIMER INFORMATION Forms heterodimers with SST2 RECEPTORS. Dimerization results in cross-modulation of receptor phosphorylation, internalization and desensitization METHOD Immunoprecipitation REFERENCES 11896051

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory