| Details: |
| NAME |
EXTRACELLULAR CALCIUM-SENSING RECEPTOR_CASR_Rattus norvegicus |
| DESCRIPTION |
Extracellular calcium-sensing receptor precursor (CaSR) (ParathyroidCell calcium-sensing receptor) (PCaR1). |
| SPECIES |
Rattus norvegicus |
COMMON NAME |
Rat |
NCBI Taxonomy |
10116 |
| GENE |
Casr | Gprc2a | Pcar1 |
| SEQUENCE |
MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQY
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWA
SSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIA
KEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQILICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSS
SLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQ
PRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCA
DADSEMTIQETGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS
|
FRAGMENT |
NO
|
|
|
|
|
Homepage
|
| Dimerization: |
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Bioluminescence Resonance Energy Transfer (BRET)
|
REFERENCES |
12383267
|
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Functional complementation of inactive mutant receptors
|
REFERENCES |
9722601
|
| HOMODIMER INFORMATION |
There is experimental evidence for homo-dimerization
|
METHOD |
Immunoprecipitation
|
REFERENCES |
10077597
|
| HETERODIMER INFORMATION |
Forms heterodimers with Metabotropic Glutamate Receptor 1.
|
METHOD |
Immunoprecipitation
|
REFERENCES |
11489900
|
| HETERODIMER INFORMATION |
Forms heterodimers with Metabotropic Glutamate Receptor 5.
|
METHOD |
Immunoprecipitation
|
REFERENCES |
11489900
|
| Scaffold: |
| TYPE |
alpha-filamin/ABP280( actin binding protein 280)
|
REFERENCES |
11390380 | 1223909
|
| Coupling with G-proteins: |
| Family:G12/13 |
REFERENCES: | 12954603 | | 1 | GPR0036 | Galpha-12-Rattus norvegicus | | Family:Gi/o |
REFERENCES: | 11152759 | | 2 | GPR0026 | Galpha-o-Rattus norvegicus | | 3 | GPR0111 | Galpha-i3-Rattus norvegicus | | 4 | GPR0221 | Galpha-i1-Rattus norvegicus | | 5 | GPR0229 | Galpha-i2-Rattus norvegicus | | Family:Gq/11 |
REFERENCES: | 8255296 | | 6 | GPR0032 | Galpha-11-Rattus norvegicus | | 7 | GPR0242 | Galpha-q-Rattus norvegicus |
|
biol.uoa.gr
for comments, corrections and
data (sequence) submission.
