gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0311 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B1(Adrenoceptor)

Cross References:
UniProt O70430 EMBL AF055349
InterPro IPR000276 GPCRDB ADRB1_MERUN
PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Meriones unguiculatus
DESCRIPTION Beta-1 adrenergic receptor .
SPECIES Meriones unguiculatus COMMON NAME Mongolian jird NCBI Taxonomy 10047
GENE ADRB1
SEQUENCE
ISALVSFLPILMHWWRAENDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVY
LRVFREAQKQVKK
FRAGMENT YES

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12140284 | 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE CN-ras-GEF( cAMP-depented Ras exchange factor) /nRAP-GEP/RA-GEF REFERENCES 12391161
TYPE Endophilin1-3( SH3p4,SH3p8,SH3p13) REFERENCES 10535961
TYPE GIPC( GAIP-interacting protein) REFERENCES 12724327
TYPE MAGI-2( membrane-associated guanylate kinase protein inverted 2) /S-SCAM REFERENCES 11526121
TYPE Nck, Grb3 REFERENCES 9843378 | 11384839
TYPE PSD95( postsynaptic density protein) REFERENCES 10995758

Coupling with G-proteins:
No information


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