gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0312 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY ADRENOCEPTOR (B-ADRENOCEPTOR)
SUBFAMILY B1(Adrenoceptor)

Cross References:
UniProt P07700 EMBL M14379
InterPro IPR000507 | IPR002233 | IPR000276 PDB 1DEP GPCRDB ADRB1_MELGA
PRINTS PR01103 | PR00561 | PR00237 PFAM PF00001

Details:
NAME ADRENOCEPTOR (B-ADRENOCEPTOR)_B1(Adrenoceptor)_Meleagris gallopavo
DESCRIPTION Beta-1 adrenergic receptor (Beta-1 adrenoceptor) (Beta-1adrenoreceptor) (Beta-T).
SPECIES Meleagris gallopavo COMMON NAME Common turkey NCBI Taxonomy 9103
GENE ADRB1
SEQUENCE 
MGDGWLPPDCGPHNRSGGGGATAAPTGSRQVSAELLSQQWEAGMSLLMALVVLLIVAGNV
LVIAAIGRTQRLQTLTNLFITSLACADLVMGLLVVPFGATLVVRGTWLWGSFLCECWTSL
DVLCVTASIETLCVIAIDRYLAITSPFRYQSLMTRARAKVIICTVWAISALVSFLPIMMH
WWRDEDPQALKCYQDPGCCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKEQIRK
IDRCEGRFYGSQEQPQPPPLPQHQPILGNGRASKRKTSRVMAMREHKALKTLGIIMGVFT
LCWLPFFLVNIVNVFNRDLVPDWLFVFFNWLGYANSAFNPIIYCRSPDFRKAFKRLLCFP
RKADRRLHAGGQPAPLPGGFISTLGSPEHSPGGTWSDCNGGTRGGSESSLEERHSKTSRS
ESKMEREKNILATTRFYCTFLGNGDKAVFCTVLRIVKLFEDATCTCPHTHKLKMKWRFKQ
HQA
 FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12140284 | 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12244098
HETERODIMER INFORMATION Forms heterodimers with B2 Adrenoceptors. Dimerization results in inhibiting internalization and ERK activation by B2 Adrenoceptor METHOD Immunoprecipitation REFERENCES 12140284

Scaffold:
TYPE CN-ras-GEF( cAMP-depented Ras exchange factor) /nRAP-GEP/RA-GEF REFERENCES 12391161
TYPE Endophilin1-3( SH3p4,SH3p8,SH3p13) REFERENCES 10535961
TYPE GIPC( GAIP-interacting protein) REFERENCES 12724327
TYPE MAGI-2( membrane-associated guanylate kinase protein inverted 2) /S-SCAM REFERENCES 11526121
TYPE Nck, Grb3 REFERENCES 9843378 | 11384839
TYPE PSD95( postsynaptic density protein) REFERENCES 10995758

Coupling with G-proteins:
No information

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory