gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0577 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CC)
SUBFAMILY CCR5

Cross References:
UniProt O97880 EMBL AF075445
InterPro IPR002240 | IPR000355 | IPR000276 GPCRDB CCR5_PYGBI
PRINTS PR00657 | PR01110 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CC)_CCR5_Pygathrix bieti
DESCRIPTION C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(CD195 antigen).
SPECIES Pygathrix bieti COMMON NAME Black snub-nosed monkey NCBI Taxonomy 61621
GENE CCR5 | CMKBR5
SEQUENCE
MDYQVSSPTYDIDYYTSEPCQKVNVKQIAARLLPPLYSLVFIFGFVGNILVVLILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQREGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCYIFQQEAPERASSVYTRSTGEQEISVGL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12089144
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725362
HETERODIMER INFORMATION Forms heterodimers with Chemokine CCR2 Receptor. Dimerization increases the sensitivity and range of signalling pathways activated METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11350939

Coupling with G-proteins:
No information


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory