gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0584 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY CHEMOKINE RECEPTOR (CC)
SUBFAMILY CCR5

Cross References:
UniProt O97883 EMBL AF075451
InterPro IPR002240 | IPR000355 | IPR000276 GPCRDB CCR5_HYLLE
PRINTS PR00657 | PR01110 | PR00237 PFAM PF00001

Details:
NAME CHEMOKINE RECEPTOR (CC)_CCR5_Hylobates leucogenys
DESCRIPTION C-C chemokine receptor type 5 (C-C CKR-5) (CC-CKR-5) (CCR-5) (CCR5)(CD195 antigen).
SPECIES Hylobates leucogenys COMMON NAME White-cheeked gibbon NCBI Taxonomy 61853
GENE CCR5 | CMKBR5
SEQUENCE
MDYQVSSPTYDIDYDTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILVLINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAIVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKHFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Bioluminescence Resonance Energy Transfer (BRET) REFERENCES 12089144
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 10725362
HETERODIMER INFORMATION Forms heterodimers with Chemokine CCR2 Receptor. Dimerization increases the sensitivity and range of signalling pathways activated METHOD Immunoprecipitation, Fluorescence Resonance Energy Transfer (FRET) REFERENCES 11350939

Coupling with G-proteins:
No information


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athina University of Athens
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Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory