gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0755 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY DOPAMINE RECEPTOR
SUBFAMILY D1

Cross References:
UniProt P21728 | Q4QRJ0 EMBL X55760 | X58987 | X55758 | S58541 | AB065677 | AF498961 | BC074978 | BC074979 | BC096837
InterPro IPR015694 | IPR001413 | IPR000929 | IPR000276 PDB 1OZ5 GPCRDB DRD1_HUMAN
GENEID 1812 MIM 126449
PRINTS PR00565 | PR00242 | PR00237 PFAM PF00001

Details:
NAME DOPAMINE RECEPTOR_D1_Homo sapiens
DESCRIPTION D(1A) dopamine receptor.
SPECIES Homo sapiens COMMON NAME Human NCBI Taxonomy 9606
GENE DRD1
SEQUENCE
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
FRAGMENT NO

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Dimerization:
HOMODIMER INFORMATION There is experimental evidence for homo-dimerization METHOD Immunoprecipitation REFERENCES 9804783
HETERODIMER INFORMATION Forms heterodimers with Adenosine A1 Receptor. Heterodimerization results in altered D1 receptor signalling METHOD Immunoprecipitation REFERENCES 10890919

Coupling with G-proteins:
Family:Gs REFERENCES:11238742
1GPR0103Galpha-olf-Homo sapiens-2
2GPR0310Galpha-olf-Homo sapiens-1
3GPR0119Galpha-s-Homo sapiens-2
4GPR0263Galpha-s-Homo sapiens-4
5GPR0266Galpha-s-Homo sapiens-5
6GPR0267Galpha-s-Homo sapiens-6
7GPR0277Galpha-s-Homo sapiens-7
8GPR0278Galpha-s-Homo sapiens
9GPR0395Galpha-s-Homo sapiens-3


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athina University of Athens
Faculty of Biology
Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory