gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::GPCR View
Entry 1 of 1 :: GPCR0086 ::
CLASS CLASS A (RHODOPSIN LIKE)
FAMILY 5-HYDROXYTRYPTAMINE RECEPTOR
SUBFAMILY 5-HT-2C

Cross References:
UniProt P08909 EMBL M21410
InterPro IPR000377 | IPR002231 | IPR000276 GPCRDB 5HT2C_RAT
GENEID 25187
PRINTS PR00517 | PR01101 | PR00237 PFAM PF00001

Details:
NAME 5-HYDROXYTRYPTAMINE RECEPTOR_5-HT-2C_Rattus norvegicus
DESCRIPTION 5-hydroxytryptamine receptor 2C (5-HT-2C) (Serotonin receptor 2C) (5-HT2C) (5-HTR2C) (5HT-1C).
SPECIES Rattus norvegicus COMMON NAME Rat NCBI Taxonomy 10116
GENE Htr2c | 5ht1c | Htr1c
SEQUENCE 
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALS
IVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYV
WPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVW
AISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIY
VLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRG
TMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGY
VCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRH
TNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
 FRAGMENT NO

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Scaffold:
TYPE MUPP1( multiple activated protein kinase 1) REFERENCES 11150294
TYPE PSD95( postsynaptic density protein) REFERENCES 12006486
TYPE Veli3( vertebrate homologue pf C.elegans Lin-7) REFERENCES 12682061

Coupling with G-proteins:
Family:G12/13 REFERENCES:14722258 | 11572865
1GPR0036Galpha-12-Rattus norvegicus
Family:Gq/11 REFERENCES:1302605
2GPR0032Galpha-11-Rattus norvegicus
3GPR0242Galpha-q-Rattus norvegicus

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athina University of Athens
 Faculty of Biology
 Dept. of Cell Biology and Biophysics
Biophysics
& Bioinformatics
Laboratory