gpDB: a database of GPCRs, G-proteins, Effectors and their interactions
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gpDB::G-protein View
Entry 1 of 1 :: GPR0039 ::
CLASS Galpha
FAMILY Gq/11
SUBFAMILY Galpha-14
TYPE Galpha-14

Cross References:
UniProt P38408 EMBL D90335
InterPro IPR001019 | IPR000654 | IPR011025
PRODOM PD000281
GENEID 281789
PRINTS PR00318 | PR00442 PFAM PF00503

Details:
NAME Galpha-14-Bos taurus
DESCRIPTION Guanine nucleotide-binding protein alpha-14 subunit (GL1).
SPECIES Bos taurus COMMON NAME Bovine NCBI Taxonomy 9913
POST TRANSLATION MODIFICATIONS null GENE GNA14
SEQUENCE 
MAGCCCLSAEEKESQRISAEIERQLRRDKKDARRELKLLLLGTGESGKSTFIKQMRIIHG
SGYSDEDRKGFTKLVYQNIFTAMQAMIRAMDTLKIQYVCEQNKENAQLIREVEVDKVSTL
SRDQVEAIKQLWQDPGIQECYDRRREYQLSDSAKYYLTDIDRIAMPAFVPTQQDVLRVRV
PTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFESVTSIIFLVALSEYDQVLAECDN
ENRMEESKALFKTIITYPWFLNSSVILFLNKKDLLEEKIMYSHLISYFPEYTGPKQDVKA
ARDFILKLYQDQNPDKEKVIYSHFTCATDTENIRFVFAAVKDTILQLNLREFNLV
 FRAGMENT NO
FUNCTION Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Effectors:
1EFF0347GRK2-Bos taurusInhibits PLC-beta activation and blocks Gqa-mediated GLUT4 translocation and glucose uptake in 3T3 adipocytes15251227 | 14654303 | 16182515
2EFF0516Phospholipase C beta-1-Bos taurusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615
3EFF0554Phospholipase C beta-4-Bos taurusStimulation of PLC-beta catalytic activity15251227 | 16182515 | 11015615

Coupling with GPCRs:
No information



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